Priyanka S. Ruparelia – Preliminary Thesis Defense 8/23/2016 at 10:30 A.M.
JSNN – Priyanka S. Ruparelia – Ph.D. Preliminary Thesis Defense
Candidate: Priyanka S. Ruparelia
Advisor: Dr. Dennis LaJeunesse
Date: Tuesday, August 23, 2016
Time: 10:30 A.M. – 12:30 P.M.
Location: JSNN Auditorium2907 E. Gate City Blvd., Greensboro, NC 27401
Title: “Cellulose Polymeric Material: A Parenteral for Tissue Engineering and Regenerative Medicine Technology.”
The dimension that sits at the convergence of chemistry, physics, and biology, and defined as a basic unit of life is Nanometer. The tissues in the human body are composed of nanostructures that assist in various tissue-specific functions. These nanostructures can be classified into four types, namely protective tissues, mechano-sensitive tissues, electro-active tissues and stress-sensitive tissues. Inspired from these natural frameworks, Smallness has formed a strong foundation in the field of Tissue Engineering (TE) and Regenerative Medicine Technology. Tissue Engineering is the repair and restoration of a damaged tissue or organ using nano topography-guided structures that form biological scaffolds. Scaffolds are biomaterials that mimic the native tissue environments and promote cellular regeneration and tissue formation. With over 400 billion dollars spent by the US to treat tissue loss annually, it is extremely pertinent to test sustainable and biocompatible materials that can replace or regenerate damaged tissue. In this study, I propose a very specific way to understand nanoscale scaffold-cell interactions using two classes of Cellulose-based biomaterials i.e., Cellulose Acetate and Bacterial Cellulose. In my proposed studies, I will use NIH/3T3 fibroblasts and A549 cell lines to determine the mechanisms that define and control the cellular processes. Further, I will determine the role that topography of the material and alignment of the nanofibers in these materials have in structuring the extracellular matrix that guides cellular processes like adhesion, proliferation, migration and even differentiation. This study will also inquest in ways of characterizing the material surface, the cellular processes occurring on the scaffolds and the potential of the biomaterials to serve as a Tissue Engineering and Regenerative Medicine model.