Seminar Series: Friday, January 13, 2017 at 11:00 A.M.
JSNN Seminar Series
Title: “Nanoparticle Interactions with Skin: A Blessing or a Curse?”
Speaker: Nancy A. Monteiro-Riviere, Ph.D.
Director of Nanotechnology Innovation Center
Date and Time: Friday, 1/13/2017, 11:00 A.M.
Location: JSNN Auditorium
Skin is a potential route of exposure to engineered nanoparticles (NP) that may occur in the environment or occupational setting, or after topical dosing with cosmetic or pharmaceutical formulations. It is the one drug delivery portal for nanomaterials that has been extensively studied. There are two phases for assessing hazard and risk after such exposure: penetration and toxicity to cellular elements of the skin. The focus of this presentation is to review some of the physicochemical properties of NP that may enhance or prevent penetration and /or toxicity. There are properties of a chemical/ nanoparticle that will determine its propensity to cause dermatotoxicity which is the ability to penetrate skin and subsequently interact with the biological components of skin that could elicit a toxicological response. Due to recent advances in nanotechnology and their use in consumer products such as cosmetics, there is a concern around potential safety issues. The penetration of NP in the skin is a controversial subject, partly because many factors that influence absorption were not studied and the opinions of some investigators were generalized based on limited studies with only a few types of NP. Many of these studies were conducted on very large particles that were not of nanosize. Also, discrepancies may relate to differences in NP composition, surface chemistry, vehicles or solvents, techniques and methods of exposure, and analytical analysis, laboratory conditions and duration of the experiment. There are anatomical differences in species, hair follicle density, thickness, and regional differences in absorption that effect results. The respiratory route of exposure has been studied extensively but skin exposure has been neglected being considered less permeable with a lower perception of risk. However, nanotherapeutic delivery systems are being aggressively developed for transdermal applications and vaccine delivery making definition of realistic physiochemical properties important.
Nancy A. Monteiro-Riviere, PhD, ATS is the Regents Distinguished Research Scholar and University Distinguished Professor and Director, of the Nanotechnology Innovation Center of Kansas State. She did a postdoctoral fellowship in toxicology at Chemical Industry Institute of Toxicology in RTP, NC. She was Professor of Investigative Dermatology and Toxicology at North Carolina State University (NCSU) for 28 years and Professor in the Joint Department of Biomedical Engineering at UNC-Chapel Hill/NCSU and Research Adjunct Professor of Dermatology, at UNC-Chapel Hill School of Medicine. She was past-President of both the Dermal and In Vitro Specialty sections of the Society of Toxicology and selected as an Eminent Toxicologist in March 2016 by the National Society of Toxicology. Dr. Monteiro-Riviere is a Fellow in The Academy of Toxicological Sciences and was elected to its Board of Directors. She was the recipient of the Purdue University Inaugural Distinguished Women Scholars Award, KSU Woman of Distinction, and elected to attend the National Academy of Sciences Keck Futures Initiative. She is Associate Editor for two and serves on the editorial board of six other toxicology journals; as well as on several national (NRC) and international (EU) expert review panels. She was on Thomson Reuters’s 2014 list of the top 1% most highly cited researchers in pharmacology and toxicology. She published over 300 manuscripts in skin toxicology and nanotoxicology and is Editor of three books in toxicology: “Nanotoxicology Characterization and Dosing and Health Effects”, “Toxicology of the Skin -Target Organ Series” and the latest in CRC Press “Nanotoxicology: Progress toward Nanomedicine”. Her research interests involve in vivo and in vitro studies of skin absorption, penetration and toxicity of chemicals, nanoparticles, and the effect of the biocorona on uptake and cellular responses to nanomaterials.