Komal Garde – Seminar/Ph.D. Thesis Defense – Thursday, October 19, 2017 at 2:00 P.M.

JSNN – Komal Garde – Ph.D. Thesis Defense/Thursday Seminar

Candidate: Komal Garde

Advisor and Committee Chair: Shyam Aravamudhan, Ph.D.

Department: Nanoengineering

Date: Thursday, October 19, 2017

Time: 2:00 P.M. – 4:00 P.M.

Location: JSNN 209 Open Room

2907 E. Gate City Blvd., Greensboro, NC 27401

Title: “Application of Electrical Stimulation via Nanoelectrodes to Modulate Adipose Derived Stem Cells.”

Abstract:

With the advent of electroceuticals/bioelectronic medicine, electrical stimulation (ES) is being explored extensively to modulate biological processes. The primary objective of this research is to explore how ES can facilitate differentiation of Adipose derived stem cells (ADSC) into neural lineage. First, ADSCs were extracted from liposuction/surgical fat tissue, and differentiated using established differentiation protocols using growth factors and chemicals. Next, nanoelectrodes of optimal size and shape were fabricated using microfabrication techniques to gain intracellular access to cells. These electrodes were then used to electrically stimulate ADSCs to explore the differentiation of ADSCs to neuronal lineage.