Joseph M. Starobin, Ph.D.
Associate Professor, Nanoscience
- Development and implementation of quasi-stationary analysis of QT/RR interval hysteresis and QT/RR interval fluctuations for non-invasive diagnostics of cardiac ischemia and arrhythmias.
- Organizing and leading interdisciplinary clinical and experimental biomedical studies in collaboration with Cleveland Clinic, Duke Medical Center, Environmental Protection Agency, Brody School of Medicine at East Carolina University, Moses Cone Health System (Greensboro, NC) and UNCG Department of Exercise and Sport Science.
- Development of theory of vulnerability and rate-dependent restitution in biological excitable media.
- Development of theory of wavefront-obstacle interactions to explain a mechanism of initiation of cardiac tachyarrhythmias in ischemic cardiac tissue.
- Mathematical modeling of blood flows in cavities of the artificial heart.
Development of theory of diffraction of electromagnetic waves on thin superconducting films.
Prof. Starobin's professional career has been devoted to the application of methods of theoretical, mathematical and computational physics to cardiovascular research. In collaboration with his colleagues at MIT and Naval Research Laboratory he has developed an exactly solvable reaction-diffusion model. The Chernyak-Starobin-Cohen model allows one to determine analytically the stable steady-state wave-train solutions and to compute basic cycle length curves that describe the underlying properties of wave propagation in excitable media. A major product of his earlier research was the development and implementation of the theoretical analysis of reaction-diffusion media for predicting cardiac ischemia and malignant cardiac arrhythmias under conditions of quasi-stationary exercise.
The emphasis of Prof. Starobin’s current research is on improving the quality of electrophysiological data collection with MEMS and nano-enabled sensors. This work along with the extensive mathematical modeling of the dynamics of non-linear waves will eventually result in clinical implementation of the methods that he has developed so far using smaller, smarter and less costly electrophysiological devices.
- J.M.Starobin, C.P.Danford, V.Varadarajan, A.J.Starobin, V.N.Polotski, Critical scale of propagation influences dynamics of waves in a model of excitable medium, Nonlinear Biomedical Physics, 2009, 3:4
- J.M.Starobin, W.E. Cascio, A.H.Goldfarb, V.Varadarajan, A.J.Starobin, C.P.Danford and T.A.Johnson, Identifying coronary flow reduction and ischemia using quasi-stationary QT/RR interval hysteresis measurements. J. of Electrocardiology, 2007, 40: S91 – S96
- M.S.Lauer, C.E.Pothier, Y.B.Chernyak, R.Brunken, M.Lieber, C.Apperson-Hansen and J.M.Starobin, Exercise-induced QT/RR interval hysteresis as a predictor of myocardial ischemia. J. of Electrocardiology, 2006, 39: 315-323
- Y.B.Chernyak, J.M.Starobin and R.J.Cohen, Where do dispersion curves end? A basic question in theory of excitable media. Phys. Rev. E, 1998, 58: 4108-4111
- Y.B.Chernyak, J.M.Starobin and R.J.Cohen, Class of exactly solvable models of excitable media. Phys. Rev. Letters, 1998, 80: 5675-5678
- J.M.Starobin and C.F.Starmer, Boundary layer analysis of waves propagating in an excitable medium: Medium conditions for wavefront-obstacle separation. Phys. Rev. E, 1996, 54: 430-437
- J.M.Starobin, Y.I.Zilberter, E.M.Rusnak and C.F.Starmer, Wavelet formation in excitable cardiac tissue: The role of wavefront-obstacle interactions in initiating high frequency fibrillatory-like arrhythmias. Biophysical Journal, 1996, 70:581-594
- Y.I.Zilberter, C.F.Starmer, J.M.Starobin and A.O.Grant, Late Na channels in cardiac cells: The physiological role of background Na channels. Biophysical Journal, 1994, 67:153-160
- V.N.Aleksandrov, E.M.Gershenson, G.N.Gol’tsman, J.M.Starobin and V.N.Trifonov, Optimization of the sensitive element of a superconducting film bolometer. Superconductivity (Sov. Sverkhprovodimost’: Fizika, Khimiya, Tekhnika), 1990, part 1, 3(8):1407-1415
- J.M.Starobin, Y.B.Chernyak Method and system for evaluating arrhythmia risk with QT-RR interval data sets, US Patent No.7,123,953, 2006
- J.M.Starobin, Y.B.Chernyak Method and system for evaluating cardiac ischemia with an exercise protocol, US Patent No.7,104,961, 2006
- J.M.Starobin, Y.B.Chernyak Method and system for evaluating cardiac ischemia with heart rate feedback, US Patent No.6,768,919, 2004
- J.M.Starobin, Y.B.Chernyak Method and system for evaluating and locating cardiac ischemia, US Patent No. 6,648,829, 2003
- J.M.Starobin, Y.B.Chernyak Method and system for evaluating cardiac ischemia with an abrupt stop exercise protocol, US Patent No. 6,648,830, 2003
- J.M.Starobin, Y.B.Chernyak Method and system for evaluating cardiac ischemia with RR-interval data sets, US Patent No.6,652,467, 2003
- J.M.Starbin, Y.B.Chernyak Method and system for evaluating cardiac ischemia with RR-interval data sets and pulse or blood pressure monitoring, US Patent No. 6,656,126, 2003
- J.M.Starobin, Y.B.Chernyak Method and system for evaluating cardiac ischemia, US Patent No. 6,663,572, 2003
- J.M.Starobin, Y.B.Chernyak Method and system for evaluating cardiac ischemia, US Patent No. 6,361,503, 2002
- J. M. Starobin, V. Varadarajan, Method and system of stimulation of nerve tissue with a sequence of spatially distributed resonant sub-threshold electrical stimuli, U.S. Patent Application No. 61/424,758,2010 (pending)
- J.M. Starobin, V. Varadarajan, W. Krassowska Neu, S.F. Idriss, Method and system for evaluating stability of propagation reserve, U.S. Patent Application No. 61/506,289, 2011 (pending)
RESEARCH GRANTS (TOTAL FUNDING $670,000)
PI - National Science Foundation Research Grant, CBET 1342051 2013-2015
PI - Environmental Protection Agency, Contract RFQ-RT-11-00201 2011-2013
Co-PI - American Heart Association/Duke University, 10CRP3040018 2010-2013
PI - MSTI Research Grant, Electrophysiology Research Program 2007-2009
PI - NIH Research Grants, R43 HL078027-01, R43 HL074501-01A1 2004-2006
PI - Whitaker Foundation Research Grant, No. 96-0161 1996-1999
Ph.D. Mechanics of Fluids
Moscow Physico-Technical Institute, 1982
M.Sc. Mathematical Physics
Moscow Physico-Technical Institute, 1975