Marinella G. Sandros, Ph.D.
Assistant Professor, Nanoscience
Phone: 336.285.2869
Fax: 336.217.5179
Email: m_sandro@uncg.edu
Research Interests
Prof. Sandros research concentration is focused on the integration of inorganic nanomaterials and polymers with biology. She has previously designed a reagentless protein-based nanobiosensor for selective small molecules detection using conformational dependent interactions between a redox active metal complex ion RuII and the surface of a CdSe nanoparticle. Prof Sandros was able to enhance the biointerface properties of InGaP@ZnS quantum dots by encapsulating them in chitosan. Along with her collaborators, she has developed a robust and stable multifunctional siRNA delivery system and amplified Surface Plasmon Resonance Imaging (SPRi) signals using nanoparticles.
Prof. Sandros future research goals aim at:
- Developing novel nano-imaging probes with enhanced biointerfacing properties for deep tissue imaging.
- Engineering a highly integrated platform that allows for molecular diagnosis targeted drug delivery, and simultaneous monitoring and treatment of cardiovascular diseases.
- Introducing new methods to enhance the sensitivity of SPRi technology for medical diagnostic.
Selected Publications
- Azari F, Sandros MG, Tabrizian M “Self-assembled Multifunctional Nanoplexes for Gene Inhibitory Therapy” submitted to ACSNano.
- Behrendt M, Sandros MG, McKinney A, McDonald K, Tabrizian M, Maysinger D “Imaging and organelle distribution of fluorescent InGaP/ZnS nanoparticles in glial cells” Nanomedicine, 4(7), 747-61, 2009.
- Sandros MG, Behrendt M, McKinney A, Maysinger D, Tabrizian M “Chitosan-modified InGaP/ZnS nanoparticles for live cell imaging of glia” ICCM-17 Proceedings, 2009.
- Sandros MG, Sarraf CB, Tabrizian M “Prodrugs in Cardiovascular Therapy” Molecules, 13(5), 1156-1178, 2008.
- Sandros MG, Behrendt M, Maysinger D, Tabrizian M “InGaP@ZnS-Enriched Chitosan Nanoparticles: A Versatile Fluorescent Probe for Deep Tissue Imaging” Advanced Functional Materials 17(18), 3724-3730, 2007.
- Sandros MG, Tabrizian M “Drug-Eluting Stents Devices: Clinical Relevance and Perspective” New Technologies in Vascular Biomaterials, Fundamentals about Stents II , ESVB, EURPROT: Strasbourg, France 15, 147-160, 2007.
- Aryal BP, Neupane KP, Sandros MG, Benson DE “Metallothioneins initiate semiconducting nanoparticle cellular toxicity” Small 2(10), 1159-63, 2006.
- Sandros MG, Shete V, Benson DE “Selective, Reversible, Reagentless Maltose Biosensing with Core-Shell Semiconducting Nanoparticles" The Analyst, 131, 229, 2006.
- Sandros MG, Gao D, Benson DE “A Modular Nanoparticle-Based System for Reagentless Small Molecule Biosensing” J. Am. Chem. Soc., 127 (35), 12198 -12199, 2005.
- Sandros MG, Gao D, Gokdemir C, Benson DE “General, high-affinity approach for the synthesis of fluorophore appended protein nanoparticle assemblies” Chem. Commun. (22), 2832 – 2834, 2005.
Patents
Sandros MG, Tabrizian M. A new class of NIR quantum dots. Patent ROI : 08016 (Under consideration), 2007Grants
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By Appointment
Post-Doctoral Studies, Biomedical Engineering
McGill University, 2006-2010
Ph.D., Bioinorganic Chemistry
Wayne State University, 2006
B.Sc., Honors Chemistry, Minor in German Studies
University of Windsor, 2001
Advanced Functional Materials
InGaP@ZnS-Enriched Chitosan Nanoparticles: A Versatile Fluorescent Probe for Deep-Tissue Imaging
Nanomedicine (2009)
"Imaging and organelle distribution of fluorescent InGaP/ZnS nanoparticles in glial cells"
J. AM. CHEM. SOC. (2005)
"A Modular Nanoparticle-Based System for Reagentless Small Molecule Biosensing"