On October 14, 2022, Day 2 will highlight the cross-disciplinary contributions from experts in the physical sciences, health care, and semiconductor technologies and focuses on five high-impact opportunity areas (OA) that include: 1. DNA-based massive information storage,  2. Energy Efficient, Small-Scale Cell-Based, and Cell-inspired Information Systems, 3. Intelligent Sensor Systems and Cell/Semiconductor Interfaces, 4. Electronic-Biological System Design Automation, and 5. Biological Pathways for Semiconductor Fabrication.