Joseph M. Starobin, Ph.D.
Associate Professor of Nanoscience
Prof. Starobin’s professional career has been devoted to the application of methods of theoretical, mathematical and computational physics to cardiovascular research. In collaboration with his colleagues at MIT and Naval Research Laboratory he has developed an exactly solvable reactiondiffusion model. The ChernyakStarobinCohen model allows one to determine analytically the stable steadystate wavetrain solutions and to compute basic cycle length curves that describe the underlying properties of wave propagation in excitable media. A major product of his earlier research was the development and implementation of the theoretical analysis of reactiondiffusion media for predicting cardiac ischemia and malignant cardiac arrhythmias under conditions of quasistationary exercise.
The emphasis of Prof. Starobin’s current research is on improving the quality of electrophysiological data collection with MEMS and nanoenabled sensors. This work along with the extensive mathematical modeling of the dynamics of nonlinear waves will eventually result in clinical implementation of the methods that he has developed so far using smaller, smarter and less costly electrophysiological devices.
 Development of noninvasive methods and miniature devices for assessing cardiovascular stress in asymptomatic population
 Experimental and theoretical methods of noninvasive diagnostics of coronary artery disease and cardiac arrhythmias.
 Design and control of peripheral neural interfaces
 Mathematical modeling of cognitive processes and memory in the brain
 Theory of nonlinear waves in excitable media.
UNC Board of Governors teaching award article https://www.northcarolina.edu/content/JosephStarobin Heart Research supported by NSF ICorps grant article https://uncgnow.uncg.edu/hearthealthyresearch/
HONORS/AWARDS
2016, 2015 Honoree, Faculty Excellence in Research and Creative Activity
2015 UNC Board of Governors Teaching Excellence Award
2012, 2014 Joint School of Nanoscience and Nanoengineering Teaching Excellence Awards
CHAPTERS
 J.M.Starobin, S.S.Gilani, S.Aravamudhan Applications of micro/nanotechnology to design and control of neural interfaces. In: Kelkar A. (ed.) Advances in Nanoscience and Nanoengineering.CRC Press, 2014: 5165
 J.M. Starobin, Y. B. Chernyak, A role of a critical excitation length scale in dynamics of reentrant cardiac arrhythmias, Herz Schrittmachertherapie & Electrophysiologie, 1999, 10(2): 119136
 Y.B.Chernyak and J.M.Starobin, Characteristic and critical excitation length scales in 1D and 2D simulations of reentrant cardiac arrhythmias using simple twovariable models. Critical Reviews in Biomedical Engineering, 1999, 27: 359 – 414
 C.F.Starmer and J.M.Starobin, Antiarrhythmic and proarrhythmic mechanisms in cardiac tissue: Linking spiral waves, reentrant arrhythmias and electrocardiographic patterns. In: Spooner P.M., Joyner R.W., Jalife J. (eds.) Discontinuous Conduction in the Heart. Futura Publishing Company, Armonk, NY, 1997, pp.321394
SELECTED ARTICLES PAPERS IN REFEREED JOURNALS

 S.R.Meier, J.L.Lancaster, D. Fetterhoff, R.A.Kraft, R.E.Hampson and J.M.Starobin The relationship between Nernst equilibrium variability and the multifractality of interspike intervals in the hippocampus, Journal of Computational Neuroscience, 2016, DOI 10.1007/s1082701606335
 K.Kosaraju, J.L.Lancaster, S.R.Meier, S.Crawford, S.Hurley, S.Aravamudhan and J.M.Starobin Noninvasive evaluation of cardiac repolarization in mice exposed to singlewall carbon nanotubes and ceria nanoparticles via intratracheal instillation, Environmental Science: Nano, 2016, 3, 611618
 M. S. Hazari, J. L. Lancaster, J. M. Starobin, A. K. Farraj and W. E. Cascio. Diesel exhaust worsens cardiac conduction instability in dobutaminechallenged WistarKyoto and spontaneously hypertensive rats, Cardiovascular Toxicology, 2016. http://link.springer.com/article/10.1007/s1201201693631
 S.R.Meier, J.L.Lancaster, J.M.Starobin, Bursting regimes in a reactiondiffusion system with action potentialdependent equilibrium. PLoS ONE, 2015, 10(3):e0122401. Doi:10.1371/journal. Pone. 0122401
 J.L.Lancaster, T.Antonijevic, J.M.Starobin, Odering and stability in lipid droplets with applications to lowdensity lipoproteins. Physical Review E, 2014, 89:062708
 S.A.Vance, E.Zeidan, L.B.Williams, J.M.Starobin, and M.G.Sandros, An easy method to synthesize carboncoated quantum dots. Nano LIFE, 2013, 3: 1340006(16)
 J.M.Starobin and V.Varadarajan, Entrainment of marginally stable excitation waves by spatially extended subthreshold periodic forcing. Nonlinear Biomedical Physics, 2011, 5:8
 C.P.Danford, V.Varadarajan, A.J.Starobin, V.N.Polotski, and J.M.Starobin, Cardiac restitution and electrographic stress testing. J. of Electrocardiology, 2009, 42: 619
 J.M.Starobin, C.P.Danford, V.Varadarajan, A.J.Starobin, and V.N.Polotski, Critical scale of propagation influences dynamics of waves in a model of excitable medium. Nonlinear Biomedical Physics, 2009, 3:4
 V.N.Polotski , V.Varadarajan, A.J.Starobin, C.P.Danford , W.E. Cascio, T.A.Johnson, and J.M.Starobin, Relation between cardiac restitution and flow limitation in an experimental model of coronary artery disease. J. of Electrocardiology, 2008, 41: 646
 J.M.Starobin, W.E. Cascio, A.H.Goldfarb, V.Varadarajan, A.J.Starobin, C.P.Danford and T.A.Johnson, Identifying coronary flow reduction and ischemia using quasistationary QT/RR interval hysteresis measurements. J. of Electrocardiology, 2007, 40: S91 – S96
 M.S.Lauer, C.E.Pothier, Y.B.Chernyak, R.Brunken, M.Lieber, C.AppersonHansen and J.M.Starobin, Exerciseinduced QT/RR interval hysteresis as a predictor of myocardial ischemia. J. of Electrocardiology, 2006, 39: 315323
 I.B.Schwartz, I.Triandaf, J.M.Starobin and Y.B.Chernyak, Origin of quasiperiodic dynamics in excitable media. Phys. Rev. E, 2000, 61: 7208 – 7211
 Y.B.Chernyak, J.M.Starobin and R.J.Cohen, Where do dispersion curves end? A basic question in theory of excitable media. Phys. Rev. E, 1998, 58: 41084111
 Y.B.Chernyak, J.M.Starobin and R.J.Cohen, Class of exactly solvable models of excitable media. Phys. Rev. Letters, 1998, 80: 56755678
 J.M.Starobin, C.F.Starmer and A.J.Starobin, Boundarylayer analysis of a spiral wave core: Spiral core radius and conditions for the tip separation from the core boundary. Phys. Rev. E, 1997, 56: 37573760
 J.M.Starobin and C.F.Starmer, A common mechanism links spiral wave meandering and wavefrontobstacle separation. Phys. Rev. E, 1997, 55: 11931196
 C.F.Starmer and J.M.Starobin, Spiral tip movement: The role of the action potential wavelength in polymorphic cardiac arrhythmias. International Journal of Bifurcation and Chaos, 1996, 6, 19091923
 J.M.Starobin and C.F.Starmer, Boundary layer analysis of waves propagating in an excitable medium: Medium conditions for wavefrontobstacle separation. Phys. Rev. E, 1996, 54: 430437
 J.M.Starobin, Y.I.Zilberter, E.M.Rusnak and C.F.Starmer, Wavelet formation in excitable cardiac tissue: The role of wavefrontobstacle interactions in initiating high frequency fibrillatorylike arrhythmias. Biophysical Journal, 1996, 70:581594
 Y.I.Zilberter, C.F.Starmer, J.M.Starobin and A.O.Grant, Background sodium current and electrical instabilities in cardiac cells. Biophysical Journal, 1995, 68, part 2, A158
 C.F.Starmer, D.N.Romashko, R.S.Reddy, Y.I.Zilberter, J.M.Starobin, A.O.Grant and V.I.Krinsky, Proarrhythmic response to potassium channel blockade: Numerical studies of polymorphic tachyarrhythmias. Circulation, 1995, 92:595605
 S.V.Biryukov, V.A. Il’in, M.D. Kitaigorodskii, I.A.Semin, N.V.Soina, J.M.Starobin, Absorption of microwave radiation by endcoupled Josephson junctions in the widebanddetection regime. J. of Communications Technology and Electronics, 1994, 34(12):105107
 Y.I.Zilberter, C.F.Starmer, J.M.Starobin and A.O.Grant, Late Na channels in cardiac cells: The physiological role of background Na channels. Biophysical Journal, 1994, 67:153160
 J.M.Starobin, Y.I.Zilberter and C.F.Starmer, Vulnerability in onedimensional excitable media. Physica D, 1994, 70:321341
 V.N.Polotskii and J.M.Starobin, Maximum efficiency of peristaltic transport, Fluid Dynamics, 1993, 28(2):289293
 J.M.Starobin, N.V.Soina, S.V.Biryukov and A.B.Ozherel’ev, Electromagnetic characteristics of the superconducting microwave waveguide elements in the resistive state. Superconductivity, 1990, part 1, 3(10):16111619
 V.N.Aleksandrov, E.M.Gershenson, G.N.Gol’tsman, J.M.Starobin and V.N.Trifonov, Optimization of the sensitive element of a superconducting film bolometer. Superconductivity (Sov. Sverkhprovodimost’: Fizika, Khimiya, Tekhnika), 1990, part 1, 3(8):14071415
 J.M.Starobin, On the influence of edge effects on the scattering of electromagnetic waves by a thin metallic strip in a rectangular waveguide. J. of Communications Technology and Electronics, 1990 35(14):131134
 J.M.Starobin, Scattering of electromagnetic waves by a resistive metal strip grating on a dielectric substrate in a rectangular waveguide. J. of Communications Technology and Electronics (Sov. Akademiya Nauk, Radiotekhnika I Elektronika), 1991, 36(7):2429
 J.M.Starobin, Electromagnetic wave scattering by metal resistive strips grating on a dielectric substrate. University News, Radio Physics, 1990 33(5):639642
 S.V.Biryukov, N.V.Soina and J.M.Starobin, Mathematical modeling of electromagnetic wave scattering on film waveguide bolometers. Electrical Engineering: UHF Electronics, 1989, 2(416):2325 (in Russian)
 S.V.Biryukov and J.M.Starobin, Mathematical modeling of electromagnetic wave scattering by resistive strips in a rectangular waveguide. Electrical Engineering: UHF Electronics (Sov. Elektronnaya tekhnika: Seriya 1, Elektronika SVCh), 1989 1(415):2831 (in Russian)
 J.M.Starobin, N.V.Soina and S.V.Biryukov, Scattering of electromagnetic waves by a thin conductive strip in a rectangular waveguide. University News, Radio Physics (Sov. Izvestiya Vuzov, Radiofizika), 1988 31(12):15361539
 J.M.Starobin, Comparative analysis of viscous flows in cavities and channels containing axisymmetrical obstacles. Fluid Dynamics, 1988, 23(3):372377
 J.M.Starobin, S.P.Lupachev, R.V.Dolgopolov and Yu.A.Morov, Analysis of hydrodynamics losses for various types of aortic valves. Mechanics of Composite Materials, 1985 21(3):349354
 J.M.Starobin and V.M.Zaiko, Numerical modeling of blood flow in the ventricular cavity of the artificial heart. Artificial Organs, 1983, 7(1):122125
 J.M.Starobin and V.M.Zaiko, Mathematical modeling of blood flow in cavities with moving boundaries. In: Modern Problems of Biomechanics (Sov. Sovremennye Problemy Biomekhaniki), Riga Academy Press, 1983, 1:5972 (in Russian)
 V.M.Zaiko, J.M.Starobin, A.N.Sharikov and Yu.V.Saakyan, Computerized system of scientific research in artificial heart problems II. Methods and Software. In: Problems of Cybernetics, Implementation of mathematical methods and computers in cardiology and surgery (Sov. Voprosy Kibernetiki, Primenenie Matematicheskikh Metodov I Vychislitel’noy Tekhniki v Kardiologii I Khirurgii), Science, Moscow, 1983, 6587 (in Russian)
 J.M.Starobin, Flow of a viscous liquid in a bent tube of finite length undergoing deformation. Fluid Dynamics, 1981, (16)2:301304
 J.M.Starobin, Flow of a viscous liquid in the gap between a moving and a fixed sphere at low Reynolds numbers. Fluid Dynamics (Sov. Izvestiya Akademii Nauk, Mekhanika Zhidkosti I Gaza), 1980, 15(6):938941
 V.M.Zaiko, A.V.Utkin and J.M.Starobin, Numerical modeling of the peristaltic fluid flow in a tube with a wall that deforms according to a harmonic law. Mechanics of Composite Materials, 1979, 15(5):597600
 J.M.Starobin and V.M.Zaiko, Numerical study of the flow of a viscous fluid through a deforming tube. Mechanics of Composite Materials, 1979, 15(4):427431
 V.M.Zaiko, J.M.Starobin and A.V.Utkin, Numerical simulation of the movement of a viscous fluid (blood) in a tube with an actively deforming wall. Mechanics of Composite Materials (Sov. Mekhanika Kompozitnykh Materialov), 1979, 15(3):301306
 V.I.Shumakov, V.M.Zaiko and J.M.Starobin, Numerical modeling of the motion of a disk mitral valve in the left cardiac ventricle. Polymer Mechanics (Sov. Mekhanika Polimerov), 1978, 14(3):407412
 J.M. Starobin, V. Varadarajan, W. Krassowska Neu, and S.F. Idriss, Method and system for evaluating stability of propagation reserve, U.S. Patent Application No.14/130,363, Published: August 28, 2014 (pending)
 J. M. Starobin and V. Varadarajan, Method and system of stimulation of nerve tissue with a sequence of spatially distributed resonant subthreshold electrical stimuli, U.S. Patent No. 8, 855,787, 2014
 J.M.Starobin and Y.B.Chernyak Method and system for evaluating arrhythmia risk with QTRR interval data sets, US Patent No.7,123,953, 2006
 J.M.Starobin and Y.B.Chernyak Method and system for evaluating cardiac ischemia with an exercise protocol, US Patent No.7,104,961, 2006
 J.M.Starobin and Y.B.Chernyak Method and system for evaluating cardiac ischemia with heart rate feedback, US Patent No.6,768,919, 2004
 J.M.Starobin and Y.B.Chernyak Method and system for evaluating and locating cardiac ischemia, US Patent No. 6,648,829, 2003
 J.M.Starobin and Y.B.Chernyak Method and system for evaluating cardiac ischemia with an abrupt stop exercise protocol, US Patent No. 6,648,830, 2003
 J.M.Starobin and Y.B.Chernyak Method and system for evaluating cardiac ischemia with RRinterval data sets, US Patent No.6,652,467, 2003
 J.M.Starobin and Y.B.Chernyak Method and system for evaluating cardiac ischemia with RRinterval data sets and pulse or blood pressure monitoring, US Patent No. 6,656,126, 2003
 J.M.Starobin and Y.B.Chernyak Method and system for evaluating cardiac ischemia, US Patent No. 6,663,572, 2003
 J.M.Starobin and Y.B.Chernyak Method and system for evaluating cardiac ischemia, US Patent No. 6,361,503, 2002
 S.P.Dolgopolov, G.V.Morov, and J.M.Starobin Hydrodynamic device for testing the heart artificial valves, 1986, USSR patent No. 1299586
 J.M.Starobin and V.M.Zaiko Method of testing the cardiovascular system during cardiosurgical operations, 1986, USSR patent No. 1263223