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How Nanomaterials interact with Biological Systems

The interaction of synthetic organic and inorganic nanomaterials with living cells is a critical area of research that several faculty members at the JSNN are pursuing and has potential applications in medicine, including drug delivery and tissue engineering. Tetyana Ignatova, an Assistant Professor in the Department of Nanoscience at the JSNN, in collaboration with colleagues at Lehigh University and Penn State University, has just published in Biophysical Reports a detailed study describing the cellular intake of DNA-wrapped single-walled carbon nanotubes by stem cells (doi: In a series of experiments using a combination of biological assays, flow cytometry, and confocal Raman microscopy, the researchers identified several mechanisms of cellular intake and how they depend on the different phases of the cell cycle. Ongoing collaborative work will continue exploring the factors affecting cell differentiation and will be extended to other types of cells and other types of nanomaterials.

(Image credit: S.S. Jedlicka, S.V. Rodkin et al. J. Mater. Chem. B 2017, 5, 6536-6545)